Implications of physiological changes in pregnancy in COVID-19

Pregnant women generally constitute a group at high risk of infectious diseases due to gestational immunological and physiological changes in their system. That is why the objective of this work is to analyze the implications of the physiological changes of pregnancy in SARS-CoV-2 disease. Physiological changes in pregnant women not only increase their susceptibility to the virus, but also increase the severity of the disease. Changes in the respiratory and immune systems, the role of the placenta in coagulation, and the function of endothelial cells are the physiological changes that most influence the disease. The decrease in lung capacity and the variations that occur in the immune system represent new treatment challenges for pregnant women with COVID-19 disease and therefore new areas of research limited so far.

Mini -Review of the Significance of Vitamin-C in the Management of Novel Corona Virus

Introduction: A newly discovered COVID-19 is a communicable disease which is caused by corona virus. The corona virus disease 2019 pandemic has affected 100 million people in the worldwith just about 22,69,466 deaths occurred to date.In management of covid-19 Vitamin C has various physiological functions, many of which are includes immunomodulatory,antioxidant, anti-inflammatory and antithrombotic functions. In the systematic reviewwe reviewed the feasibility of accessible evidence on significance of nutrient C in treatment of patients with corona virus. Methods: To accessing the importance of vitamin C in patients with corona virus we taken already various research published article, meta-analysis,systematic review and randomized control trails on role of nutrient C. The web of science, pubmedand scopus were obtained and using specified search query.For producing the graph and plots weworking on R-studio application. Results: We were looking different wellsprings of role of vitamin and Coronavirus. The time frame from 2020-2021 an inquiry created found of 254 reports from 173 Sources (Journals, Books,article and so forth) the quantity of writers included 1477, Authors of single-composed archives were 17, multi-wrote records were 1460, writers per archive was 5.81and co-writers per archive was 6.26. The Collaboration Index and Average references per archive was 6.16 and5.6. Conclusion: In this article after finding of many article we evaluated the significance roles of vitamin C as a multiple functions of antiviral, antioxidant, and immunosuppressed. Although in the fight against corona virus there is currently no proof from completed randomized controlled trials to decisively and specifically indicate a role for vitamin supplementation. Some study has proved there is strong scientific evidence, builded on learning of vitamin physiology, pharmacology. Battle against this worldwide pandemic some clinical studies of ARDS and infection to preferable a role for vitamins C. A valuable number of ongoing studies should provide solid evidence to inform and decision-makers and researchers shortly. © The Electrochemical Society

Phase Separation: "The Master Key" to Deciphering the Physiological and Pathological Functions of Cells.

Phase separation is a hot research field at present. It involves almost all aspects of cells and plays a significant role in cells, promising to be "a master key" in unlocking the mysteries of nature. In this review, the factors that affect phase separation are introduced, such as own component, electrostatic interaction, and chemical modification. Furthermore, the physiological roles of phase separation in cells, including molecules transport channel, gene expression and regulation, cellular division and differentiation, stress response, proteins refolding and degradation, cell connections, construction of skin barrier, and cell signals transmission, are highlighted. However, the disorder of phase separation leads to pathological condensates, which are associated with neurodegenerative diseases, tumors, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This relationship is considered the potential target for developing corresponded drugs and therapy. Some drugs targeting phase separation have improved meaningful, such as tankyrase, lipoamide, oligonucleotides, elvitagravir, nilotinib, CVL218, PJ34. All in all, mystery phase separation provides a new viewpoint for researchers to explore cells, and is expected to solve many unknown phenomena in nature.

Severity assessment of single-dose Oxford-AstraZeneca vaccinated individuals infected with severe acute respiratory syndrome coronavirus 2 in Southeast Bangladesh

Background and Aim: A vaccine program for coronavirus illness (coronavirus disease [COVID-19]) is currently underway in numerous regions of the world, including Bangladesh, but no health data on those who have been vaccinated are available at this time. The study aimed to investigate the health condition of people who had received their first dose of the Oxford- AstraZeneca vaccine and were infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Materials and Methods: To detect SARS-CoV-2, a standard virological approach, real-time reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR), was used. Several health indicators from vaccinated patients were collected using pre-structured questionnaires during the infection phase.

The molecular mechanism by which vitamin D protects against COVID-19

The SARS-CoV2 virus, which causes COVID-19, exerts its pathophysiological effect by intensively binding to the angiotensin-converting enzyme 2 receptor (ACE2) on the host cells. By blocking the ACE2 receptor, the physiological functions of the cell are inhibited, which are important for the normal function of various organs, and especially for the protection of the lungs. Therefore, the number of functionally active ACE2 receptors is extremely important for the body's resistance to COVID19. More receptors equal greater resistance of the host. An increased number of ACE2 receptors gives the body more time to mobilize an adequate immune response. Experience to date from the immediate fight against COVID19 has confirmed this rule: (A) women are generally more resistant (the ACE2 receptor gene is on the X chromosome, and women have two X chromosomes), (B) younger people are more resistant to the virus (ACE2 expression decreases with age), (C) patients with chronic diseases are more sensitive (have a reduced number of ACE2). Therefore, an increase in the number of ACE2 receptors is extremely important for the body's protective power in the fight against the SARS-CoV2 virus. Vitamin D increases the expression of the ACE2 gene, which increases the number of ACE2 receptors, which can be of significant aid in the fight against COVID-19.